Associate Professor of Biology, University of North Carolina at Chapel Hill; affiliated with Curriculum in Genetics, Biochemistry and Biophysics graduate program and Bioinformatics and Computational Biology graduate program
A.B. Princeton University, 1996
Ph.D. Duke University, 2001
I find thinking about cells and training people to be scientists an absoultely fascinating, challenging and rewarding life. I love new microscopes, puzzling data and starting new collaborations. You can read more about me here.
Ph.D. Duke University, 2016
I am interested in how cells regulate nanometer sized proteins to assemble dynamic, micron-scaled cytoskeletal structures. In the Gladfelter lab I study the highly conserved septin cytoskeleton using genetic and biophysical approaches coupled with high resolution microscopy. I love being a scientist because thinking creatively is just as important as thinking analytically.
José Vargas-Muñiz, Ph.D.
B.S. University of Puerto Rico-Mayagüez, BS Industrial Biotechnology, 2012.
Ph.D. Duke University, 2017
Septins, a conserved family of GTP-binding cytoskeletal proteins, serve as micron-scale plasma membrane curvature sensors. Septins assembles into higher-order structures, which serve as platforms to recruit other proteins. At the Gladfelter lab, I am characterizing septin-protein interaction with an emphasis on interaction that are dependent on curvature. I love science because it allows me to use my curiosity and creativity to better understand the world that surround us.
B.S. University of Pittsburgh, 2010
PhD Yale University, 2018
I study how cells use RNA sequence and structure to encode mesoscale biophysical properties of liquid-like droplets of protein and RNA. I am also interested in understanding and manipulating these liquid-like droplets in normal and diseased states.
B.S. University of Pittsburgh, 2013
PhD University of Texas at Austin, 2018
I am interested in how cellular membranes compartmentalize and organize the cell to facilitate essential functions. In the Gladfelter Lab, I study how membranes control the patterning and assembly of liquid-like droplets of protein and RNA. I enjoy using diverse biophysics and microscopy toolsets to answer challenging questions in biology. I love science for the freedom to explore fascinating questions using new and creative approaches.
B.S. Saint Joseph’s University, 2012
Understanding how the septin cytoskeleton interacts with membranes and senses micron-scale curvature. I love being a scientist because I get to think about beautiful things and use my imagination everyday.
B.S. University of Nebraska – Lincoln, 2014
As a joint project with Jay Dunlap and Jennifer Loros at Dartmouth College, my work focuses on elucidating the spatiotemporal dynamics of the circadian clock in Neurospora crassa and how this simple circadian system is regulated at the level of individual hyphae. Being a scientist allows me to be part of a collaborative, global community that works toward gaining a better understanding of how life works. Interacting with such a diverse group of individuals with different life experiences and perspectives is one of my favorite aspects of being a scientist.
B.S. Truman State University 2011
My project involves understanding spatial control of phase separation to achieve functional compartmentalization of syncytial cytoplasm. Previous work in the lab has shown that a single polyQ RNA-binding protein, Whi3, phase-separates to position cyclin and formin mRNA transcripts in spatially distinct locations in the cytosol to regulate nuclear cycling and polarity. My work seeks to determine if and how local phase separation of Whi3 is used to regulate polarity and cell cycle responses independently of one and other as well as if Whi3 is regulating translatability of its target mRNAs in addition to positioning them.
Class of 2021
Graduate and Postdoc Alumni